Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Phenylboronic Acid | HCID 66827 | — |
| Reactant | HCID 178478306 | HCID 178478306 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 178420133 | HCID 178420133 | — |
Reaction Steps
To 5-chloro-7-(4H-1,2,4-triazol-3-yl)benzo[c][2,6]naphthyridine (21.3 mg), cesium carbonate (49 mg) and phenylboronic acid (19 mg) in dioxane (1 mL) was added PdCl2(dppf) under nitrogen atmosphere. The mixture stirred at 120° C. at 300 W (microwave) for 10 min. Water was added and residue obtained after extraction with dichloromethane was purified by preparative HPLC. LCMS (ES) m/z [M+1]+ 324.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08168651B2 |
|---|
| Source dataset | uspto-grants-2012_05 |
|---|
| ORD ID | ord-f237d34f07a74536b1eb625492d52d0e |
|---|
| Source note | uspto-grants-2012_05 |
|---|
