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HRID1919694

反应详情

EQUATION

反应方程式

HRID 1919694 的结构方程式

REACTANTS

反应物

4
结构：O
HCID962

Water

H2O

结构：O=C([O-])[O-].[Cs+].[Cs+]
HCID10796

Cesium carbonate

CCs2O3

结构：OB(O)c1ccccc1
HCID66827

Boronic acid, phenyl-

C6H7BO2

结构：Clc1nc2c(-c3nnc[nH]3)cccc2c2cnccc12
HCID178478306

未命名化合物

PRODUCTS

生成物

1
结构：c1ccc(-c2nc3c(-c4nnc[nH]4)cccc3c3cnccc23)cc1
HCID178420133

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：Cl[Pd]Cl.[Fe+2].c1ccc(P(c2ccccc2)[c-]2cccc2)cc1.c1ccc(P(c2ccccc2)[c-]2cccc2)cc1
催化剂HCID178418228

Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)

C34H28Cl2FeP2Pd

结构：C1COCCO1
溶剂HCID31275

1,4-Dioxane

C4H8O2

CONDITIONS

反应条件

温度
120 °C

PROCEDURE

实验过程

To 5-chloro-7-(4H-1,2,4-triazol-3-yl)benzo[c][2,6]naphthyridine (21.3 mg), cesium carbonate (49 mg) and phenylboronic acid (19 mg) in dioxane (1 mL) was added PdCl2(dppf) under nitrogen atmosphere. The mixture stirred at 120° C. at 300 W (microwave) for 10 min. Water was added and residue obtained after extraction with dichloromethane was purified by preparative HPLC. LCMS (ES) m/z [M+1]+ 324.

WORKUP

后处理

  1. customresidue obtained
  2. extractionafter extraction with dichloromethane
  3. customwas purified by preparative HPLC