反应详情

4-[1,1,1,3,3,3-Hexafluoro-2-(methoxymethyl)oxypropan-2-yl]-2-propylphenyl 4-bromobutyl ether (70 mg, 0.15 mmol), 1,5,5-trimethylimidazolidine-2,4-dione (24.8 mg, 0.17 mmol) and potassium carbonate (31.1 mg, 0.23 mmol) were added, followed by stirring overnight at room temperature. The reaction solution was extracted with ethyl acetate-water, and the organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting residue was purified by silica gel preparative thin-layer chromatography (hexane:ethyl acetate=3:1) to obtain 78.8 mg of the title compound (yield: 100%) as a colorless oil.

1. extractionThe reaction solution was extracted with ethyl acetate-water
2. dry with materialthe organic layer was dried over anhydrous sodium sulfate
3. concentrationconcentrated under reduced pressure
4. customThe resulting residue was purified by silica gel preparative thin-layer chromatography (hexane:ethyl acetate=3:1)