反应详情

温度

60 °C

A 2 mol/L Lithium hydroxide solution (2 mL) was added to a mixed solution of 5-[4-[1,1,1,3,3,3-hexafluoro-2-(methoxymethyl)oxypropan-2-yl]-2-propylphenyloxy]pent-2-yl acetate (80.4 mg, 169 μmol) in methanol (1.5 mL) at room temperature, followed by heating at an external temperature of 60° C. in an oil bath overnight. After completion of the reaction, methanol was evaporated under reduced pressure. The pH was adjusted to 7 by adding 4 mol/L hydrochloric acid (2 mL) to the residue. After extraction with chloroform-water, the organic layer was washed with a saturated sodium chloride solution and dried over sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure. 68.1 mg of the title compound (yield: 93%) was obtained as a colorless oil.

1. customwas evaporated under reduced pressure
2. additionby adding 4 mol/L hydrochloric acid (2 mL) to the residue
3. extractionAfter extraction with chloroform-water
4. washthe organic layer was washed with a saturated sodium chloride solution
5. dry with materialdried over sodium sulfate
6. filtrationAfter filtration
7. concentrationthe filtrate was concentrated under reduced pressure