3,4-Dichlorophenyl isocyanate → HCID 59235276, compound

HRID 1919775Notes

Reaction equation

HRID 1919775 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]([NH:14][CH3:15])[C:10]([O:12]C)=O)[CH:6]=[CH:7][CH:8]=1.[Cl:16][C:17]1[CH:18]=[C:19]([N:24]=[C:25]=[O:26])[CH:20]=[CH:21][C:22]=1[Cl:23]>C1COCC1>[Cl:16][C:17]1[CH:18]=[C:19]([N:24]2[C:10](=[O:12])[CH:9]([C:5]3[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=3)[N:14]([CH3:15])[C:25]2=[O:26])[CH:20]=[CH:21][C:22]=1[Cl:23]

Participants

4

Reactant 2

HCID 76073,4-Dichlorophenyl isocyanateHCID 59235275HCID 59235275, compound

Product 1

HCID 59235276HCID 59235276, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3 g of methyl 2-(3-methoxyphenyl)-2-methylaminoacetate were introduced into a 250 mL Woulff bottle at ambient temperature. 2.7 g d of 3,4-dichlorophenyl isocyanate in 50 mL of THF were added and the mixture was stirred for 30 min at ambient temperature. The insoluble matter was filtered, washed with isopropyl ether and dried to yield the product in the form of a white solid (3.9 g; Yd=75%).

Workup

  1. additionwere added
  2. filtrationThe insoluble matter was filtered
  3. washwashed with isopropyl ether
  4. customdried
  5. customto yield the product in the form of a white solid (3.9 g; Yd=75%)

Sources & evidence

ORD record
ord-b4e1c66887064757b0d9976c35f549a8
Source dataset
uspto-grants-2012_05
Patent number
US08168667B2

Reaction notes

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