反应详情

10.5 mL of boron trifluoride/dimethyl sulphide complex are added dropwise, at ambient temperature, to 3.7 g of a solution of 3-(3,4-dichlorophenyl)-5-(3-methoxyphenyl)-1-methylimidazolidine-2,4-dione in 60 mL of dichloromethane in a flask equipped with a magnetic stirrer and a nitrogen intake. After 2 hours at ambient temperature, the mixture is poured over a saturated aqueous sodium bicarbonate solution and subjected to extraction with ethyl acetate. The mixture is dried over magnesium sulphate and concentrated. The residue is crystallised in isopropyl ether (white solid; m=3 g; Yd=84%).

1. customequipped with a magnetic stirrer
2. extractionsubjected to extraction with ethyl acetate
3. dry with materialThe mixture is dried over magnesium sulphate
4. concentrationconcentrated
5. customThe residue is crystallised in isopropyl ether (white solid; m=3 g; Yd=84%)