Dimethylformamide → HCID 59235231, compound

HRID 1919777Notes

Reaction equation

HRID 1919777 reaction equation
[O:1]=[C:2]1[NH:6][C:5]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=2)([CH2:7][C:8]#[CH:9])[C:4](=[O:18])[N:3]1[C:19]1[CH:26]=[CH:25][C:22]([C:23]#[N:24])=[C:21]([C:27]([F:30])([F:29])[F:28])[CH:20]=1.[CH3:31]N(C=O)C>>[O:1]=[C:2]1[N:6]([CH3:31])[C:5]([C:10]2[CH:11]=[CH:12][C:13]([O:16][CH3:17])=[CH:14][CH:15]=2)([CH2:7][C:8]#[CH:9])[C:4](=[O:18])[N:3]1[C:19]1[CH:26]=[CH:25][C:22]([C:23]#[N:24])=[C:21]([C:27]([F:30])([F:28])[F:29])[CH:20]=1

Participants

3

Reactant 2

HCID 6228DimethylformamideHCID 59235254HCID 59235254, compound

Product 1

HCID 59235231HCID 59235231, compound

Procedure

Following the procedure of Example 159, a solution of 380 mg of 4-[2,5-dioxo-4-(4-methoxyphenyl)-4-(2-propynyl)imidazolidin-1-yl]-2-trifluoromethylbenzonitrile in 9 mL of DMF is treated to produce 580 mg of crude product which is purified by chromatography over silica while eluting with (90/10 then 85/15) heptane/ethyl acetate mixture. 320 mg of product are obtained in the form of a white solid (Yd=81%).

Workup

  1. customto produce 580 mg of crude product which
  2. customis purified by chromatography over silica
  3. washwhile eluting with (90/10

Sources & evidence

ORD record
ord-2be0f51fa19e424886b82b26dd8c3371
Source dataset
uspto-grants-2012_05
Patent number
US08168667B2

Reaction notes

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