HCID 59235234, compound → HCID 59235235, compound

HRID 1919778Notes

Reaction equation

HRID 1919778 reaction equation
C([O:4][CH2:5][C:6]#[C:7][CH2:8][N:9]1[C:13]([C:15]2[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=2)([CH3:14])[C:12](=[O:22])[N:11]([C:23]2[CH:28]=[CH:27][C:26]([Cl:29])=[C:25]([Cl:30])[CH:24]=2)[C:10]1=[O:31])(=O)C>C(O)C.Cl>[Cl:30][C:25]1[CH:24]=[C:23]([N:11]2[C:12](=[O:22])[C:13]([C:15]3[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=3)([CH3:14])[N:9]([CH2:8][C:7]#[C:6][CH2:5][OH:4])[C:10]2=[O:31])[CH:28]=[CH:27][C:26]=1[Cl:29]

Participants

3

Reactant 1

HCID 59235234HCID 59235234, compound

Product 1

HCID 59235235HCID 59235235, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 21887872Ethanol hydrochlorideSolvent

Procedure

500 mg 4-[1-(3,4-dichlorophenyl)-2,5-dioxo-4-(4-hydroxyphenyl)-4-methylimidazolidin-3-yl]-2-butynyl acetate (the product of Example 223) are dissolved in 10 mL of a 2 N ethanol/HCl mixture (70/30). The mixture is stirred under reflux for 3 hours then concentrated and dried under vacuum. 400 mg of a white solid are obtained (Yd=99%).

Workup

  1. temperatureunder reflux for 3 hours
  2. concentrationthen concentrated
  3. customdried under vacuum

Sources & evidence

ORD record
ord-4788b1c6dd664d278978d737a3a6847e
Source dataset
uspto-grants-2012_05
Patent number
US08168667B2

Reaction notes

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