HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → Methyl 2-amino-2-(4-hydroxyphenyl)propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Methyl 2-(4-acetoxyphenyl)-2-bromopropionate | HCID 59235280 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Methyl 2-amino-2-(4-hydroxyphenyl)propionate | HCID 59235258 | — |
Reaction Steps
10 g of methyl 2-(4-acetoxyphenyl)-2-bromopropionate, 50 mL of THF and 30 mL of ethanol are introduced into a Woulff bottle at ambient temperature. The mixture is saturated with gaseous ammonia and stirred for one night at ambient temperature. The insoluble matter is filtered and purified over a silica column with 90/10 dichloromethane/methanol to yield the product (5 g; Yd=77%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08168667B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-b9d517dfee4d495194fecb5bf9fbcd19 |
| Source note | uspto-grants-2012_05 |