反应详情

10 g of methyl 2-(4-acetoxyphenyl)-2-bromopropionate, 50 mL of THF and 30 mL of ethanol are introduced into a Woulff bottle at ambient temperature. The mixture is saturated with gaseous ammonia and stirred for one night at ambient temperature. The insoluble matter is filtered and purified over a silica column with 90/10 dichloromethane/methanol to yield the product (5 g; Yd=77%).

1. filtrationThe insoluble matter is filtered
2. custompurified over a silica column with 90/10 dichloromethane/methanol
3. customto yield the product (5 g; Yd=77%)