Hydrochloric Acid → HCID 59235214, compound

HRID 1919786Notes

Reaction equation

HRID 1919786 reaction equation
ClC1C=CC(C=[N:9][C:10]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)([CH2:15][C:16]#[CH:17])[C:11]([O:13][CH3:14])=[O:12])=CC=1.Cl>C(OCC)C.O>[NH2:9][C:10]([C:18]1[CH:19]=[CH:20][C:21]([O:24][CH3:25])=[CH:22][CH:23]=1)([CH2:15][C:16]#[CH:17])[C:11]([O:13][CH3:14])=[O:12]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 59235262HCID 59235262, compound

Product 1

HCID 59235214HCID 59235214, compoundYield 92.6%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 3283Diethyl EtherSolvent

Procedure

962 mg of the compound prepared in Stage 2 are stirred at AT in 14 mL of ethyl ether and 3.5 mL of 1 N hydrochloric acid for 18 hours. The mixture is diluted with water and the product is extracted with ethyl acetate. The solvent is dried over magnesium sulphate and evaporated to produce 584 mg of product, in the form of colourless oil (Yd=92%).

Workup

  1. extractionthe product is extracted with ethyl acetate
  2. dry with materialThe solvent is dried over magnesium sulphate
  3. customevaporated

Sources & evidence

ORD record
ord-959d3aca1275449f98c8042e62b98237
Source dataset
uspto-grants-2012_05
Patent number
US08168667B2

Reaction notes

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