4-Fluoro-3-(trifluoromethyl)benzonitrile → HCID 67500530, compound

HRID 1919828Notes

Reaction equation

HRID 1919828 reaction equation
CN1CC[CH:5]([O:8][C:9]2[CH:14]=[CH:13][C:12]([CH:15]([NH2:17])[CH3:16])=[CH:11][C:10]=2[C:18]([F:21])([F:20])[F:19])[CH2:4][CH2:3]1.FC1C=CC(C#N)=CC=1C(F)(F)F.[CH3:35][O:36][C@@H](C)CO>>[CH3:35][O:36][C@@H:4]([CH3:3])[CH2:5][O:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]([NH2:17])[CH3:16])=[CH:11][C:10]=1[C:18]([F:21])([F:20])[F:19]

Participants

4

Reactant 3

HCID 1442554-Fluoro-3-(trifluoromethyl)benzonitrileHCID 6424022-Methoxy-1-propanol, (2S)-HCID 67500773HCID 67500773, compound

Product 1

HCID 67500530HCID 67500530, compound

Procedure

The title compound was synthesized according to the procedure described for the synthesis of 1-[4-[(1-methylpiperidin-4-yl)oxy]-3-(trifluoromethyl)phenyl]ethanamine, part A and B, starting from 4-fluoro-3-(trifluoromethyl)benzonitrile and (S)-(+)-2-methoxypropanol.

Sources & evidence

ORD record
ord-0e0a06b79df942febf149935a4ee60f1
Source dataset
uspto-grants-2012_05
Patent number
US08168668B2

Reaction notes

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