HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → [1-(6-Tert-butyl-2-methoxypyridin-3-yl)ethyl]amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | Tetrahydrofuran toluene | HCID 22635083 | — |
| Reactant | 6-Tert-butyl-2-methoxynicotinonitrile | HCID 66745229 | — |
| Reactant | [1-(6-Tert-butylpyridin-3-yl)ethyl]amine | HCID 67500288 | — |
| Reactant | HCID 178418689 | HCID 178418689 | — |
| Product | [1-(6-Tert-butyl-2-methoxypyridin-3-yl)ethyl]amine | HCID 67499814 | — |
Reaction Steps
The title compound was synthesized according to the procedure described for the synthesis of [1-(6-tert-butylpyridin-3-yl)ethyl]amine starting from 6-tert-butyl-2-methoxynicotinonitrile (intermediate 23) (66 mg, 0.347 mmol), MeMgBr 1.4 M 75/25 toluene/THF (743 μL, 1.04 mmol) and NaBH4 (32.8 mg, 0.87 mmol Material isolated from the workup was used without further purification in the preparation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08168668B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-0e4bc44383f74a4dbcbaff24d437378a |
| Source note | uspto-grants-2012_05 |