1,4-Dioxane hydrochloride → HCID 67496791, compound

HRID 1919919Notes

Reaction equation

HRID 1919919 reaction equation
[NH:1]([C:8](=[O:27])[CH:9]([C:14]1[CH:26]=[CH:25][C:17]([C:18]([O:20]C(C)(C)C)=[O:19])=[CH:16][CH:15]=1)[CH2:10][N:11]([CH3:13])[CH3:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:28].O1CCOCC1>>[ClH:28].[NH:1]([C:8](=[O:27])[CH:9]([C:14]1[CH:15]=[CH:16][C:17]([C:18]([OH:20])=[O:19])=[CH:25][CH:26]=1)[CH2:10][N:11]([CH3:12])[CH3:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 57611859HCID 57611859, compound

Product 1

HCID 67496791HCID 67496791, compound

Procedure

tert-Butyl 4-{2-anilino-1-[(dimethylamino)methyl]-2-oxoethyl}benzoate (350 mg, 0.95 mmol) was taken up in 4 M HCl/dioxane (10 mL) and stirred at room temperature for 16 h. The solution was concentrated to dryness to give 4-{2-anilino-1-[(dimethylamino)methyl]-2-oxoethyl}benzoic acid hydrochloride as a white, flaky solid. MS (ESI) calcd [M+H]+ 313.1, found 313.1.

Workup

  1. concentrationThe solution was concentrated to dryness

Sources & evidence

ORD record
ord-fe7ccb13b7074f98ab976f961f8d74f7
Source dataset
uspto-grants-2012_05
Patent number
US08168658B2

Reaction notes

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