Cyclopropanecarbonyl chloride → HCID 44159063, compound

HRID 1919929Notes

Reaction equation

HRID 1919929 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5](I)=[C:6]([CH:11]=1)[CH2:7][NH:8][CH2:9][CH3:10].[CH:13]1([C:16](Cl)=[O:17])[CH2:15][CH2:14]1.C([O:21][C:22](=[O:41])[CH2:23][C:24]1[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[C:26](B2OC(C)(C)C(C)(C)O2)[CH:25]=1)C>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:28]2[C:27]([O:30][CH3:31])=[CH:26][CH:25]=[C:24]([CH2:23][C:22]([OH:41])=[O:21])[CH:29]=2)=[C:6]([CH2:7][N:8]([C:16]([CH:13]2[CH2:15][CH2:14]2)=[O:17])[CH2:9][CH3:10])[CH:11]=1

Participants

4

Reactant 3

HCID 77637Cyclopropanecarbonyl chlorideHCID 58120060[4-Methoxy-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid ethyl esterHCID 58148919(5-Bromo-2-iodo-benzyl)-ethyl-amine

Product 1

HCID 44159063HCID 44159063, compound

Procedure

{4′-Bromo-2′-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-6-methoxy-biphenyl-3-yl}-acetic acid (Compound 1-247) was prepared by following the procedures of Example 1 using the following materials: (5-bromo-2-iodo-benzyl)-ethyl-amine, cyclopropanecarbonyl chloride, and [4-methoxy-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid ethyl ester.

Sources & evidence

ORD record
ord-af77ff822a47404293dedbff0c8eef68
Source dataset
uspto-grants-2012_05
Patent number
US08168678B2

Reaction notes

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