Potassium Carbonate → HCID 66968332, compound

HRID 1920108Notes

Reaction equation

HRID 1920108 reaction equation
[Cl:1][C:2]1[CH:35]=[CH:34][C:5]([C:6]([N:8]2[CH2:13][CH2:12][N:11]([CH:14]3[CH2:18][N:17]([C:19]4[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][C:20]=4[NH:26][C:27]([NH2:29])=[O:28])[CH2:16][CH:15]3[O:30]C(=O)C)[CH2:10][CH2:9]2)=[O:7])=[CH:4][CH:3]=1.C([O-])([O-])=O.[K+].[K+]>CO>[Cl:25][C:22]1[CH:23]=[CH:24][C:19]([N:17]2[CH2:16][CH:15]([OH:30])[CH:14]([N:11]3[CH2:12][CH2:13][N:8]([C:6](=[O:7])[C:5]4[CH:34]=[CH:35][C:2]([Cl:1])=[CH:3][CH:4]=4)[CH2:9][CH2:10]3)[CH2:18]2)=[C:20]([NH:26][C:27]([NH2:29])=[O:28])[CH:21]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 66967994HCID 66967994, compound

Product 1

HCID 66968332HCID 66968332, compoundYield 50%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of acetic acid 4-[4-(4-chloro-benzoyl)-piperazin-1-yl]-1-(4-chloro-2-ureido-phenyl)-pyrrolidin-3-yl ester (60 mg, 0.11 mmol) in MeOH (2 mL), was added K2CO3 (30 mg). The mixture was stirred for 2 h. After concentrating, the residue was purified by column chromatography (ethyl acetate:MeOH:Et3N: 10:1:0.1)) to give the desired product (20 mg, 50% yield) as a yellow oil. MS (ESI), M/Z, 478 (M+1). Retention time: 1.68 min (FA-polar).

Workup

  1. concentrationAfter concentrating
  2. customthe residue was purified by column chromatography (ethyl acetate:MeOH:Et3N: 10:1:0.1))

Sources & evidence

ORD record
ord-ba866ae9cabc473da0c0e3c2e6da82ad
Source dataset
uspto-grants-2012_05
Patent number
US08168788B2

Reaction notes

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