反应详情

A solution of 5-amino-1,2-dimethyl-1H-imidazole-4-carbonitrile (8.5 g, 62 mmol) in bromoform (51 mL) was cooled with an ice water bath, and tert-butyl nitrite (12.87 g, 124.8 mmol) was added dropwise. The reaction was heated on a steam bath for 30 minutes, allowed to cool, and then refrigerated. The solution was decanted to separate it from a precipitate, and then the solution was purified by column chromatography on silica gel (eluting with ethyl acetate) to provide 5.2 g (42%) of 5-bromo-1,2-dimethyl-1H-imidazole-4-carbonitrile as a bright orange solid.

1. temperatureThe reaction was heated on a steam bath for 30 minutes
2. temperatureto cool
3. customThe solution was decanted
4. customto separate it from a precipitate
5. customthe solution was purified by column chromatography on silica gel (eluting with ethyl acetate)