Ammonium Hydroxide → 4-Fluoro-3-((trifluoromethyl)sulfonyl)benzenesulfonamide

HRID 1920474Notes

Reaction equation

HRID 1920474 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][C:3]=1[S:12]([C:15]([F:18])([F:17])[F:16])(=[O:14])=[O:13].[OH-].[NH4+:20]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH2:20])(=[O:10])=[O:9])=[CH:4][C:3]=1[S:12]([C:15]([F:18])([F:17])[F:16])(=[O:14])=[O:13]

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 569728674-Fluoro-3-(trifluoromethylsulfonyl)benzenesulfonyl chloride

Product 1

HCID 250584524-Fluoro-3-((trifluoromethyl)sulfonyl)benzenesulfonamide

Procedure

reacting 4-fluoro-3-((trifluoromethyl)sulfonyl)benzenesulfonyl chloride, and aqueous ammonium hydroxide at about −5° C. to about −60° C. to provide 4-fluoro-3-((trifluoromethyl)sulfonyl)benzenesulfonamide and isolating or not isolating the 4-fluoro-3-((trifluoromethyl)sulfonyl)benzenesulfonamide;

Workup

  1. customat about −5° C. to about −60° C.

Sources & evidence

ORD record
ord-3e81d9f0ce414dccb3386db35081cdaf
Source dataset
uspto-grants-2012_05
Patent number
US08168784B2

Reaction notes

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