Triethyl phosphite → HCID 59157922, compound

HRID 1920517Notes

Reaction equation

HRID 1920517 reaction equation
[Br:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([CH2:12]Br)=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[I:14].[CH2:15]([O:17][P:18]([O:22]CC)[O:19][CH2:20][CH3:21])[CH3:16]>>[Br:1][C:2]1[C:3]([I:14])=[CH:4][CH:5]=[C:6]2[C:11]=1[CH:10]=[CH:9][C:8]([CH2:12][P:18](=[O:22])([O:19][CH2:20][CH3:21])[O:17][CH2:15][CH3:16])=[CH:7]2

Participants

3

Reactant 2

HCID 31215Triethyl phosphiteHCID 59157961HCID 59157961, compound

Product 1

HCID 59157922HCID 59157922, compound

Procedure

To 1-bromo-6-(bromomethyl)-2-iodonaphthalene (270 mg) from step 4 was added triethylphosphite (4 mL). The reaction mixture was heated at reflux for 1 hour followed by removal of excess triethylphosphite under high vacuum distillation yielding the titled product.

Workup

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for 1 hour
  3. customfollowed by removal of excess triethylphosphite under high vacuum distillation

Sources & evidence

ORD record
ord-ce7959ef63484b9485285dfba18a4c4a
Source dataset
uspto-grants-2012_05
Patent number
US08168815B2

Reaction notes

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