1-Boc-Azetidine-3-carboxylic acid → HCID 67496705, 화합물

HRID 1920568노트

반응식

HRID 1920568 반응식
[F:1][C:2]([F:7])([F:6])[C:3]([O-:5])=[O:4].N1[CH2:11][CH:10]([C:12]([NH:14][CH2:15][CH2:16][N+:17]23[CH2:24][CH2:23][CH:20]([CH2:21][CH2:22]2)[C@@H:19]([O:25][C:26](=[O:41])[C:27]([OH:40])([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH2:18]3)=[O:13])C1.C([N:49]1[CH2:52][CH:51]([C:53](O)=O)[CH2:50]1)(OC(C)(C)C)=O>>[F:1][C:2]([F:7])([F:6])[C:3]([O-:5])=[O:4].[NH:49]1[CH2:50][CH2:51][CH2:11][C@H:10]1[C:12]([NH:14][CH2:15][CH2:16][N+:17]12[CH2:18][CH2:19][CH:20]([CH2:21][CH2:22]1)[CH2:23][CH2:24]2)=[O:13].[F:1][C:2]([F:7])([F:6])[C:3]([O-:5])=[O:4].[OH:40][C:27]([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)([C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)[C:26]([O:25][C@@H:19]1[CH:20]2[CH2:21][CH2:22][N+:17]([CH2:16][CH2:15][NH:14][C:12]([C@H:52]3[CH2:51][CH2:53][CH2:2][CH2:50][NH:49]3)=[O:13])([CH2:24][CH2:23]2)[CH2:18]1)=[O:41].[F:1][C:2]([F:7])([F:6])[C:3]([O-:5])=[O:4].[OH:40][C:27]([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)([C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)[C:26]([O:25][C@@H:19]1[CH:20]2[CH2:21][CH2:22][N+:17]([CH2:16][CH2:15][NH:14][C:12]([C@@H:3]3[CH2:2][CH2:52][CH2:51][CH2:50][NH:49]3)=[O:13])([CH2:24][CH2:23]2)[CH2:18]1)=[O:41].[F:1][C:2]([F:7])([F:6])[C:3]([O-:5])=[O:4].[NH:49]1[CH2:52][CH2:51][C@H:50]1[C:12]([NH:14][CH2:15][CH2:16][N+:17]12[CH2:24][CH2:23][CH:20]([CH2:21][CH2:22]1)[C@@H:19]([O:25][C:26](=[O:41])[C:27]([OH:40])([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[C:34]1[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=1)[CH2:18]2)=[O:13]

참가 물질

6

반응물 2

HCID 27559811-Boc-Azetidine-3-carboxylic acidHCID 67495520HCID 67495520, 화합물

생성물 4

HCID 67496705HCID 67496705, 화합물HCID 67496844HCID 67496844, 화합물HCID 67498404HCID 67498404, 화합물HCID 86639175HCID 86639175, 화합물

실험 절차

These compounds, namely (R)-3-(2-Hydroxy-2,2-diphenyl-acetoxy)-1-(2-[((S)-pyrrolidine-2-carbonyl)-amino]-ethyl-1-azonia-bicyclo[2.2.2]octane trifluoroacetate, (R)-3-(2-Hydroxy-2,2-diphenyl-acetoxy)-1-[2-[((R)-piperidine-2-carbonyl)-amino]-ethyl]-1-azonia-bicyclo[2.2.2]octane trifluoroacetate, (R)-3-(2-Hydroxy-2,2-diphenyl-acetoxy)-1-[2-[((S)-piperidine-2-carbonyl)-amino]-ethyl]-1-azonia-bicyclo[2.2.2] octane trifluoroacetate and (R)-1-[2-[((S)-Azetidine-2-carbonyl)-amino]-ethyl]-3-(2-hydroxy-2,2-diphenyl-acetoxy)-1-azonia-bicyclo[2.2.2]octane trifluoroacetate are prepared analogously to (R)-1-[2-[(Azetidine-3-carbonyl)-amino]-ethyl]-3-(2-hydroxy-2,2-diphenyl-acetoxy)-1-azonia-bicyclo[2.2.2]octane trifluoroacetate [Example 191] by replacing 1-BOC-azetidine-3-carboxylic acid with the corresponding BOC protected amino acid.

출처 및 근거

ORD 기록
ord-6588edc46338448b85b3c63c572537da
출처 데이터셋
uspto-grants-2012_05
특허 번호
US08168654B2

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