1-Boc-Azetidine-3-carboxylic acid → HCID 67496705, compound

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These compounds, namely (R)-3-(2-Hydroxy-2,2-diphenyl-acetoxy)-1-(2-[((S)-pyrrolidine-2-carbonyl)-amino]-ethyl-1-azonia-bicyclo[2.2.2]octane trifluoroacetate, (R)-3-(2-Hydroxy-2,2-diphenyl-acetoxy)-1-[2-[((R)-piperidine-2-carbonyl)-amino]-ethyl]-1-azonia-bicyclo[2.2.2]octane trifluoroacetate, (R)-3-(2-Hydroxy-2,2-diphenyl-acetoxy)-1-[2-[((S)-piperidine-2-carbonyl)-amino]-ethyl]-1-azonia-bicyclo[2.2.2] octane trifluoroacetate and (R)-1-[2-[((S)-Azetidine-2-carbonyl)-amino]-ethyl]-3-(2-hydroxy-2,2-diphenyl-acetoxy)-1-azonia-bicyclo[2.2.2]octane trifluoroacetate are prepared analogously to (R)-1-[2-[(Azetidine-3-carbonyl)-amino]-ethyl]-3-(2-hydroxy-2,2-diphenyl-acetoxy)-1-azonia-bicyclo[2.2.2]octane trifluoroacetate [Example 191] by replacing 1-BOC-azetidine-3-carboxylic acid with the corresponding BOC protected amino acid.

Provenance & Evidence