HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1920654Generated: October 26, 2026
3-Ethynylpyridine → 2-(6-Amino-8-(2-pyridin-3-yl-ethynyl)-purin-9-yl)ethanol
https://huagongshe.com/reaction/1920654
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Ethynylpyridine | HCID 186003 | — |
| Reactant | 2-(6-amino-8-bromo-9H-purin-9-yl)ethanol | HCID 44572469 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 2-(6-Amino-8-(2-pyridin-3-yl-ethynyl)-purin-9-yl)ethanol | HCID 66867904 | 53.5% |
Reaction Steps
To a solution of 258 mg of 2-(6-amino-8-bromo-purin-9-yl)ethanol in a mixture of Et3N and DMF were added under an atmosphere of argon 35 mg of Pd(PPh)3Cl2, 19 mg CuI and 150 mg 3-ethynylpyridine. The mixture was stirred under argon at 60° C. for 3 hours and over night at room temperature. The precipitate was isolated, washed with water and hot ethanol and dried to give 150 mg (53%) of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08173609B2 |
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| Source dataset | uspto-grants-2012_05 |
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| ORD ID | ord-95822e1621e24a1cbbdd20d092f23c8b |
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| Source note | uspto-grants-2012_05 |
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