反应详情

温度

60 °C

To a solution of 258 mg of 2-(6-amino-8-bromo-purin-9-yl)ethanol in a mixture of Et3N and DMF were added under an atmosphere of argon 35 mg of Pd(PPh)3Cl2, 19 mg CuI and 150 mg 3-ethynylpyridine. The mixture was stirred under argon at 60° C. for 3 hours and over night at room temperature. The precipitate was isolated, washed with water and hot ethanol and dried to give 150 mg (53%) of the desired product.

1. customThe precipitate was isolated
2. washwashed with water and hot ethanol
3. customdried