HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Pyridinecarboxaldehyde → 6-Amino-9-(2-chloroethyl)-2-[(4-pyridylmethyl)amino]-purine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Pyridinecarboxaldehyde | HCID 13389 | — |
| Reactant | 9-(2-Chloroethyl)-2,6-diamino-purine | HCID 66868083 | — |
| Product | 6-Amino-9-(2-chloroethyl)-2-[(4-pyridylmethyl)amino]-purine | HCID 66868049 | — |
Reaction Steps
6-amino-9-(2-chloroethyl)-2-[(4-pyridylmethyl)amino]-purine was prepared from 4-pyridinecarboxaldehyde and 9-(2-chloroethyl)-2,6-diamino-purine according to the procedure described in example 12 step B. The crude product was purified by flash chromatography (DCM/MeOH 99.5/0.5→80:20) to give the desired product as white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173609B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-13a5356c9e924a7d939eb30b4de01d39 |
| Source note | uspto-grants-2012_05 |