4-Pyridinecarboxaldehyde → 6-Amino-9-(2-chloroethyl)-2-[(4-pyridylmethyl)amino]-purine

HRID 1920666Notes

Reaction equation

HRID 1920666 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([CH:7]=O)=[CH:3][CH:2]=1.[Cl:9][CH2:10][CH2:11][N:12]1[CH:20]=[N:19][C:18]2[C:13]1=[N:14][C:15]([NH2:22])=[N:16][C:17]=2[NH2:21]>>[NH2:21][C:17]1[N:16]=[C:15]([NH:22][CH2:7][C:4]2[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=2)[N:14]=[C:13]2[C:18]=1[N:19]=[CH:20][N:12]2[CH2:11][CH2:10][Cl:9]

Participants

3

Reactant 2

HCID 133894-PyridinecarboxaldehydeHCID 668680839-(2-Chloroethyl)-2,6-diamino-purine

Product 1

HCID 668680496-Amino-9-(2-chloroethyl)-2-[(4-pyridylmethyl)amino]-purine

Procedure

6-amino-9-(2-chloroethyl)-2-[(4-pyridylmethyl)amino]-purine was prepared from 4-pyridinecarboxaldehyde and 9-(2-chloroethyl)-2,6-diamino-purine according to the procedure described in example 12 step B. The crude product was purified by flash chromatography (DCM/MeOH 99.5/0.5→80:20) to give the desired product as white solid.

Workup

  1. customThe crude product was purified by flash chromatography (DCM/MeOH 99.5/0.5→80:20)

Sources & evidence

ORD record
ord-13a5356c9e924a7d939eb30b4de01d39
Source dataset
uspto-grants-2012_05
Patent number
US08173609B2

Reaction notes

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