HCID 54123383, compound → HCID 46941063, compound

HRID 1920703Notes

Reaction equation

[NH:1]1[CH2:5][CH2:4][C@@H:3]([C:6]([NH2:9])([CH3:8])[CH3:7])[CH2:2]1.[CH:10]1([N:13]2[C:22]3[C:17](=[CH:18][CH:19]=[C:20](F)[C:21]=3[O:23][CH3:24])[C:16](=[O:26])[C:15]3[C:27]([OH:32])=[C:28]([C:30]#[N:31])[S:29][C:14]2=3)[CH2:12][CH2:11]1.OC1C2C(=O)C3C(=C(OC)C=CC=3)NC=2SC=1C#N>>[NH2:9][C:6]([C@@H:3]1[CH2:4][CH2:5][N:1]([C:20]2[C:21]([O:23][CH3:24])=[C:22]3[C:17]([C:16](=[O:26])[C:15]4[C:27]([OH:32])=[C:28]([C:30]#[N:31])[S:29][C:14]=4[N:13]3[CH:10]3[CH2:11][CH2:12]3)=[CH:18][CH:19]=2)[CH2:2]1)([CH3:8])[CH3:7]

Participants

Reactant 3

HCID 54123383HCID 54123383, compound

HCID 59526816HCID 59526816, compound

HCID 86646221HCID 86646221, compound

Product 1

HCID 46941063HCID 46941063, compound

Procedure

The title compound is prepared from (R)-2-(pyrrolidin-3-yl)propan-2-amine (Fedji, et al., 1994) and 9-cyclopropyl-7-fluoro-3-hydroxyl-8-methoxy-4-oxo-4,9-dihydrothieno[2,3-b]quinoline-2-carbonitrile using the method described above for the preparation of 9-cyclopropyl-6-fluoro-7-((R)-3-(S)-1-(2-fluoroethylamino)ethyl)pyrrolidin-1-yl)-3-hydroxyl-8-methoxy-4-oxo-4,9-dihydrothieno[2,3-b]quinoline-2-carbonitrile.

Sources & evidence

ORD record: ord-0dd60fa0e4d642aa9ab1e3fed7baa42d
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08173636B2

Reaction notes

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