HCID 10877054, compound → HCID 59198402, compound

HRID 1920822Notes

Reaction equation

HRID 1920822 reaction equation
[C:1]([C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10](=[O:15])[C:11]([CH3:14])([CH3:13])[CH3:12])=[N:7][CH:8]=1)#[N:2].C[Al]([NH2:19])Cl>C1(C)C=CC=CC=1>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10](=[O:15])[C:11]([CH3:12])([CH3:14])[CH3:13])=[N:7][CH:8]=1)(=[NH:19])[NH2:2]

Participants

4

Reactant 2

HCID 10877054HCID 10877054, compoundHCID 55136146HCID 55136146, compound

Product 1

HCID 59198402HCID 59198402, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of N-(5-cyanopyridin-2-yl)pivalamide (1.22 g, 6.00 mmol) and MeAl(Cl)NH2 (18 mL, 0.67M solution in toluene, 12.00 mmol) in 25 mL toluene is heated at 80° C. for 15 hours. The resulting N-(5-carbamimidoylpyridin-2-yl)pivalamide is used without further purification.

Workup

  1. customThe resulting N-(5-carbamimidoylpyridin-2-yl)pivalamide is used without further purification

Sources & evidence

ORD record
ord-3833d5d80f9549c98f742202919d6417
Source dataset
uspto-grants-2012_05
Patent number
US08173647B2

Reaction notes

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