Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | HCID 59198406 | HCID 59198406 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 86639243 | HCID 86639243 | — |
Reaction Steps
A mixture of 6-morpholino-2-(tetrahydro-2H-pyran-4-yl)-4,5′-bipyrimidin-2′-amine (10 mg, 0.0343 mmol), morpholine (24 mg, 8 equiv, 0.274 mmol) in NMP (0.55 mL) was heated at 150° C. for 10 min in a microwave. The mixture was purified on HPLC to give 6-morpholino-2-tetrahydro-2H-pyran-4-yl)-4,5′-bipyrimidin-2′-amine. LCMS (m/z): 343.1 (MH+). Rt: 1.62 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08173647B2 |
|---|
| Source dataset | uspto-grants-2012_05 |
|---|
| ORD ID | ord-f43cc83f2967455bae81a97aaf9fcfc0 |
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| Source note | uspto-grants-2012_05 |
|---|
