Morpholine → HCID 86639243, compound

HRID 1920834Notes

Reaction equation

HRID 1920834 reaction equation
O1CCN([C:7]2[N:12]=[C:11](C3CCOCC3)[N:10]=[C:9]([C:19]3[CH:20]=[N:21][C:22]([NH2:25])=[N:23][CH:24]=3)[CH:8]=2)CC1.N1CCOCC1>CN1C(=O)CCC1>[N:12]1[CH:7]=[CH:8][C:9]([C:19]2[CH:24]=[N:23][C:22]([NH2:25])=[N:21][CH:20]=2)=[N:10][CH:11]=1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 59198406HCID 59198406, compound

Product 1

HCID 86639243HCID 86639243, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Conditions

Temperature
150 °C

Procedure

A mixture of 6-morpholino-2-(tetrahydro-2H-pyran-4-yl)-4,5′-bipyrimidin-2′-amine (10 mg, 0.0343 mmol), morpholine (24 mg, 8 equiv, 0.274 mmol) in NMP (0.55 mL) was heated at 150° C. for 10 min in a microwave. The mixture was purified on HPLC to give 6-morpholino-2-tetrahydro-2H-pyran-4-yl)-4,5′-bipyrimidin-2′-amine. LCMS (m/z): 343.1 (MH+). Rt: 1.62 min.

Workup

  1. customThe mixture was purified on HPLC

Sources & evidence

ORD record
ord-f43cc83f2967455bae81a97aaf9fcfc0
Source dataset
uspto-grants-2012_05
Patent number
US08173647B2

Reaction notes

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