反应详情

KHMDS (0.5M in toluene, 6.536 mL, 3.268 mmol) was added to a suspension of Ph3PCH3Br (1.216 g, 3.404 mmol) in THF (15 mL) at rt. After 1 h, benzyl 3-(3-bromophenyl)-3-formylpyrrolidine-1-carboxylate was added at −20 and then the cold bath was removed. After 2 h, the reaction was quenched with MeOH (2 mL) and sat. aq. sodium bicarbonate was added. The mixture was extracted twice with ethyl acetate and then dried (MgSO4), filtered and concentrated.

1. customthe cold bath was removed
2. waitAfter 2 h
3. customthe reaction was quenched with MeOH (2 mL) and sat. aq. sodium bicarbonate
4. additionwas added
5. extractionThe mixture was extracted twice with ethyl acetate
6. dry with materialdried (MgSO4)
7. filtrationfiltered
8. concentrationconcentrated