反应详情

To a solution of 3-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-isoxazole-5-carboxylic acid methyl ester (209 mg, 0.66 mmol) in dioxane (5 mL) was added aqueous sodium hydroxide (2 N, 2 mL). After heating at reflux for 1 h the mixture was cooled to room temperature and acidified with HCl (4 N, 2 mL). Purification by filtration and drying afforded the title compound (187 mg, 94%) which was obtained as a white solid. MS: m/e=299.1 [M−H]−.

1. temperatureAfter heating
2. temperatureat reflux for 1 h the mixture
3. customPurification
4. filtrationby filtration
5. customdrying