N-Aminomorpholine → 3-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-isoxazole-5-carboxylic acid morpholin-4-ylamide

HRID 1920905ノート

反応式

HRID 1920905 の反応式
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[CH2:13][O:14][C:15]1[CH:19]=[C:18]([C:20]([OH:22])=O)[O:17][N:16]=1.[NH2:23][N:24]1[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1>>[N:24]1([NH:23][C:20]([C:18]2[O:17][N:16]=[C:15]([O:14][CH2:13][C:3]3[C:4]([C:7]4[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=4)=[N:5][O:6][C:2]=3[CH3:1])[CH:19]=2)=[O:22])[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1

参加物

3

反応物 2

HCID 20315N-AminomorpholineHCID 674920693-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-isoxazole-5-carboxylic acid

生成物 1

HCID 468969853-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-isoxazole-5-carboxylic acid morpholin-4-ylamide収率 70%

実験手順

As described for example 12b, 3-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-isoxazole-5-carboxylic acid (65 mg, 0.22 mmol) was converted, using 4-amino-morpholine (29 mg, 0.28 mmol) instead of N-aminopyrrolidine HCl, to the title compound (58 mg, 70%) which was obtained as a white solid after purification by chromatography (silica, dichloromethane:methanol=1:0 to 9:1). MS: m/e=385.2 [M+H]+.

出典と根拠

ORDレコード
ord-a0ae7526764d4876bbc7ebf25170b0d2
出典データセット
uspto-grants-2012_05
特許番号
US08173652B2

反応ノート

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