N-Aminomorpholine → 3-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-isoxazole-5-carboxylic acid morpholin-4-ylamide

Participants

Reaction Steps

As described for example 12b, 3-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-isoxazole-5-carboxylic acid (65 mg, 0.22 mmol) was converted, using 4-amino-morpholine (29 mg, 0.28 mmol) instead of N-aminopyrrolidine HCl, to the title compound (58 mg, 70%) which was obtained as a white solid after purification by chromatography (silica, dichloromethane:methanol=1:0 to 9:1). MS: m/e=385.2 [M+H]+.

Provenance & Evidence