Methanol → Methyl 2,4-Difluorobenzoate

HRID 1921085Notes

Reaction equation

HRID 1921085 reaction equation
[F:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[CH3:12][OH:13]>>[CH3:12][O:13][C:4]([C:3]1[CH:7]=[CH:8][C:9]([F:11])=[CH:10][C:2]=1[F:1])=[O:5]

Participants

3

Reactant 2

HCID 887MethanolHCID 5880812,4-Difluorobenzoyl chloride

Product 1

HCID 2782897Methyl 2,4-Difluorobenzoate

Procedure

To 100 mL of MeOH, 2,4-difluorobenzoyl chloride (10 mL, 79.3 mmol) was added and the mixture stiffed at room temperature for 2 hours. The solvent was then evaporated affording the title compound as pale yellow oil (quantitative).

Workup

  1. customThe solvent was then evaporated

Sources & evidence

ORD record
ord-86bd4f34dbc14c0db9e171f11e8e1de9
Source dataset
uspto-grants-2012_05
Patent number
US08173659B2

Reaction notes

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