Hydrochloric Acid → 4-(2-Dimethylamino-ethoxy)-2-nitro-benzoic acid hydrochloride

HRID 1921089Notes

Reaction equation

HRID 1921089 reaction equation
C([O:5][C:6](=[O:22])[C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][N:16]([CH3:18])[CH3:17])=[CH:9][C:8]=1[N+:19]([O-:21])=[O:20])(C)(C)C.[ClH:23]>O1CCOCC1>[ClH:23].[CH3:17][N:16]([CH3:18])[CH2:15][CH2:14][O:13][C:10]1[CH:11]=[CH:12][C:7]([C:6]([OH:22])=[O:5])=[C:8]([N+:19]([O-:21])=[O:20])[CH:9]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57447330Tert-butyl 4-(2-(dimethylamino)ethoxy)-2-nitrobenzoate

Product 1

HCID 574473284-(2-Dimethylamino-ethoxy)-2-nitro-benzoic acid hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of 4-(2-dimethylamino-ethoxy)-2-nitro-benzoic acid tert-butyl ester (4.53 g, 14.61 mmol) in dioxane (100 mL) was added 37% HCl (25 mL). The mixture was stirred at room temperature for 15 hours, then the suspension was evaporated and the solid dried under vacuum at 50° C. to give the title compound as yellowish solid.

Workup

  1. customthe suspension was evaporated
  2. customthe solid dried under vacuum at 50° C.

Sources & evidence

ORD record
ord-bd683963bfb5468aa2fa38b9b2360f60
Source dataset
uspto-grants-2012_05
Patent number
US08173659B2

Reaction notes

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