Hydrogen Bromide → HCID 178419735, compound

HRID 1921151Notes

Reaction equation

HRID 1921151 reaction equation
C[O:2][C:3]1[N:8]=[CH:7][C:6]([C:9]2([CH2:15][CH2:16][CH2:17]O)[CH2:14][CH2:13][CH2:12][NH:11][CH2:10]2)=[CH:5][CH:4]=1.[BrH:19]>>[BrH:19].[Br:19][CH2:17][CH2:16][CH2:15][C:9]1([C:6]2[CH:5]=[CH:4][C:3]([OH:2])=[N:8][CH:7]=2)[CH2:14][CH2:13][CH2:12][NH:11][CH2:10]1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 59187100HCID 59187100, compound

Product 1

HCID 178419735HCID 178419735, compound

Conditions

Temperature
110 °C

Procedure

0.100 g (0.4 mmol) of 3-[3-(6-methoxypyridin-3-yl)piperidin-3-yl]propan-1-ol obtained in stage 1.3, in solution in 5 ml of aqueous hydrobromic acid (48% by weight solution), is introduced into a sealed tube. The reaction medium is stirred at 110° C. for 12 hours. This solution is then brought back to ambient temperature and concentrated under reduced pressure. The resulting residue is dissolved in methanol and evaporated twice under reduced pressure, and triturated from diethyl ether, to result, after filtration, in 0.150 g of the desired compound in the form of a brown powder.

Workup

  1. customis then brought back to ambient temperature
  2. concentrationconcentrated under reduced pressure
  3. dissolutionThe resulting residue is dissolved in methanol
  4. customevaporated twice under reduced pressure
  5. customtriturated from diethyl ether
  6. customto result
  7. filtrationafter filtration

Sources & evidence

ORD record
ord-0cc5aa44b41c40aca1c5176cd0062b10
Source dataset
uspto-grants-2012_05
Patent number
US08173669B2

Reaction notes

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