Tert-butyl (2-oxo-2,3-dihydrobenzimidazol-1-yl)acetate → [3-(2-Methoxy-2-oxoethyl)-4,6-dimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl]acetic acid

HRID 1921179Notes

Reaction equation

HRID 1921179 reaction equation
O=C1N(CC(OC(C)(C)C)=O)C2C=CC=CC=2N1.[CH3:19][O:20][C:21](=[O:43])[CH2:22][N:23]1[C:27]2[C:28]([CH3:33])=[CH:29][C:30]([CH3:32])=[CH:31][C:26]=2[N:25]([CH2:34][C:35]([O:37]C(C)(C)C)=[O:36])[C:24]1=[O:42]>>[CH3:19][O:20][C:21](=[O:43])[CH2:22][N:23]1[C:27]2[C:28]([CH3:33])=[CH:29][C:30]([CH3:32])=[CH:31][C:26]=2[N:25]([CH2:34][C:35]([OH:37])=[O:36])[C:24]1=[O:42]

Participants

3

Reactant 2

HCID 20814117Tert-butyl (2-oxo-2,3-dihydrobenzimidazol-1-yl)acetateHCID 86607784tert-Butyl [3-(2-methoxy-2-oxoethyl)-4,6-dimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl]acetate

Product 1

HCID 18449372[3-(2-Methoxy-2-oxoethyl)-4,6-dimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl]acetic acid

Procedure

Essentially following the procedures described for Intermediate 7, but using tert-butyl [3-(2-methoxy-2-oxoethyl)-4,6-dimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl]acetate from Step C in place of tert-butyl (2-oxo-3-pyridin-2-yl-2,3-dihydro-1H-benzimidazol-1-yl)acetate, the title compound was prepared. MS: m/z=293 (M+1).

Sources & evidence

ORD record
ord-2f7ad425050048c781cf78d178db65a1
Source dataset
uspto-grants-2012_05
Patent number
US08173655B2

Reaction notes

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