反应详情

A solution of the tert-butyl 2-oxo-1′-(2,2,2-trifluoroethyl)-spiro[indoline-3,4′-piperidine]-1-acetate from Step B (3.19 g, 8.01 mmol) in CH2Cl2 (16 mL) and CF3CO2H (5 mL) was stirred at ambient temperature for 17 h. Added CF3CO2H (1 mL) and stirred 1 additional hour. The mixture was concentrated in vacuo. To the resulting solid was added an HCl solution (10 mL, 2.0 M in Et2O) and the solution concentrated in vacuo. Repeated two more times to produce the hydrochloride salt of the title compound as a white solid. MS: m/z=343 (M+1).

1. concentrationThe mixture was concentrated in vacuo
2. additionTo the resulting solid was added an HCl solution (10 mL, 2.0 M in Et2O)
3. concentrationthe solution concentrated in vacuo