HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1921196Generated: November 3, 2026
Benzocaine → Ethyl 4-[(2-nitrophenyl)amino]benzoate
https://huagongshe.com/reaction/1921196
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzocaine | HCID 2337 | — |
| Reactant | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| Product | Ethyl 4-[(2-nitrophenyl)amino]benzoate | HCID 11208411 | — |
Reaction Steps
A mixture of ethyl 4-aminobenzoate (1.00 g, 6.05 mmol) and 2-fluoronitrobenzene (0.64 mL, 6.05 mmol) was heated at 160° C. for 18 h. The crude product was purified by silica gel chromatography, eluting with hexane:EtOAc—70:30, to give the title compound. MS: m/z=287 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08173655B2 |
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| Source dataset | uspto-grants-2012_05 |
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| ORD ID | ord-1bce9e30b6b64ecca1e54f2ca14efb4e |
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| Source note | uspto-grants-2012_05 |
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