反应详情

To a solution of 1-(2,6-dichlorophenyl)-6-oxo-1,6-dihydro-3-pyridinecarboxylic acid (30 mg) in DMF (0.6 mL) were added N-(3-amino-4-methylphenyl)cyclopropanecarboxamide (30 mg), HATU (60 mg) and iPr2NEt (62 mg) successively, and the mixture was stirred under a nitrogen atmosphere at room temperature for 16 hr. The reaction mixture was diluted with EtOAc (3 mL), and the resulting mixture was washed with 1 M HCl (3 mL×2), saturated aqueous NaHCO3 (3 mL×2) and brine successively, dried over MgSO4 and evaporated in vacuo. The residue was triturated with 10% MeOH in CH2Cl2, and the precipitates produced were collected by filtration to give N-{5-[(cyclopropylcarbonyl)amino]-2-methylphenyl}-1-(2,6-dichlorophenyl)-6-oxo-1,6-dihydro-3-pyridinecarboxamide (25 mg).

1. washthe resulting mixture was washed with 1 M HCl (3 mL×2), saturated aqueous NaHCO3 (3 mL×2) and brine successively
2. dry with materialdried over MgSO4
3. customevaporated in vacuo
4. customThe residue was triturated with 10% MeOH in CH2Cl2
5. customthe precipitates produced
6. filtrationwere collected by filtration