HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → 3-(5-Bromo-6-methoxy-2-methylpyridin-3-yl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 3-(6-Methoxy-2-methylpyridin-3-yl)benzonitrile | HCID 67492316 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(5-Bromo-6-methoxy-2-methylpyridin-3-yl)benzonitrile | HCID 67492547 | 30% |
Reaction Steps
A mixture of 3-(6-methoxy-2-methylpyridin-3-yl)benzonitrile (3.00 g, 13.4 mmol), N-bromosuccinimide (2.89 g, 16.08 mmol) and methanol (150 mL) is stirred 66 hr at room temperature. The solids are collected by filtration to give 3-(5-bromo-6-methoxy-2-methylpyridin-3-yl)benzonitrile (1.20 g, 30%) as a white solid. LC/MS RT 4.19 min; MS m/e=303/305 (M); NMR (CDCl3) 7.65 (2H, m), 7.60 (1H, s), 7.56 (2H, m), 4.02 (3H, s), 2.37 (3H, s).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173682B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-1858840d328c4eda9bf964e18a98de44 |
| Source note | uspto-grants-2012_05 |