Water → HCID 67492305, compound

HRID 1921327Notes

Reaction equation

HRID 1921327 reaction equation
[Br:1]Br.[CH3:3][C:4]1[NH:5][C:6](=[O:14])[C:7]2[C:12]([CH:13]=1)=[CH:11][CH:10]=[CH:9][CH:8]=2.O>C(O)(=O)C>[Br:1][C:13]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=[O:14])[NH:5][C:4]=1[CH3:3]

Participants

5

Reactant 3

HCID 962WaterHCID 24408BromineHCID 32444773-Methyl-1,2-dihydroisoquinolin-1-one

Product 1

HCID 67492305HCID 67492305, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

A solution of bromine 491 mL, 9.58 mmol) in acetic acid (10 mL) is added to a stirred solution of 3-methyl-2H-isoquinolin-1-one (1.45 g, 9.12 mmol) in acetic acid (1 mL). After 3 hr, water (60 mL) is added and the resulting solids are collected by filtration to afford 4-bromo-3-methyl-2H-isoquinolin-1-one (1.90 g, 88% yield) as a white solid. LC/MS: MS m/e=238/240 (M+H); RT 2.97 min.

Workup

  1. filtrationthe resulting solids are collected by filtration

Sources & evidence

ORD record
ord-8baa1951e96148f0a2d3d109f7d27070
Source dataset
uspto-grants-2012_05
Patent number
US08173682B2

Reaction notes

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