HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 67492305, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 3-Methyl-1,2-dihydroisoquinolin-1-one | HCID 3244477 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 67492305 | HCID 67492305 | 88% |
Reaction Steps
A solution of bromine 491 mL, 9.58 mmol) in acetic acid (10 mL) is added to a stirred solution of 3-methyl-2H-isoquinolin-1-one (1.45 g, 9.12 mmol) in acetic acid (1 mL). After 3 hr, water (60 mL) is added and the resulting solids are collected by filtration to afford 4-bromo-3-methyl-2H-isoquinolin-1-one (1.90 g, 88% yield) as a white solid. LC/MS: MS m/e=238/240 (M+H); RT 2.97 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08173682B2 |
| Source dataset | uspto-grants-2012_05 |
| ORD ID | ord-8baa1951e96148f0a2d3d109f7d27070 |
| Source note | uspto-grants-2012_05 |