Dimethylamine → HCID 11631241, compound

HRID 1921386Notes

Reaction equation

HRID 1921386 reaction equation
[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[S:15][C:14]([S:16](Cl)(=[O:18])=[O:17])=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2].[CH3:20][NH:21][CH3:22]>>[CH3:20][N:21]([CH3:22])[S:16]([C:14]1[S:15][C:11]([C:5]2[CH:4]=[C:3]([CH2:1][CH3:2])[C:8](=[O:9])[NH:7][C:6]=2[CH3:10])=[CH:12][CH:13]=1)(=[O:18])=[O:17]

Participants

3

Reactant 2

HCID 674DimethylamineHCID 866103525-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride

Product 1

HCID 11631241HCID 11631241, compoundYield 61%

Procedure

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride is reacted with dimethylamine as described in Step 5, Example 24 to give the title compound as a solid (61% yield). LC/MS: RT 3.68 min; m/e 327 (M+H); 1H NMR (δ, ppm): 11.84 (1H, s), 7.61 (1H, d), 7.38 (1H, s); 7.28 (1H, d); 2.69 (6H, s), 2.39 (2H, q), 2.33 (3H, s), 1.07 (3H, t).

Sources & evidence

ORD record
ord-d60a83a610b94a92bf5b3a5acb1c9056
Source dataset
uspto-grants-2012_05
Patent number
US08173682B2

Reaction notes

Loading…