5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride → HCID 11667574, Verbindung
Reaktionsgleichung
[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[S:15][C:14]([S:16](Cl)(=[O:18])=[O:17])=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2].[CH3:20][O:21][CH2:22][CH2:23][NH-:24]>>[CH3:20][O:21][CH2:22][CH2:23][NH:24][S:16]([C:14]1[S:15][C:11]([C:5]2[CH:4]=[C:3]([CH2:1][CH3:2])[C:8](=[O:9])[NH:7][C:6]=2[CH3:10])=[CH:12][CH:13]=1)(=[O:18])=[O:17]Komponenten
3
Versuchsvorschrift
5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride is reacted with (2-methoxyethyl)amide as described in Step 5, Example 24 to give the title compound as a solid (26% yield). LC/MS: RT 2.51 min; m/e 357 (M+H); 1H NMR (δ, ppm): 11.82 (1H, s), 7.97 (1H, t), 7.54 (1H, d), 7.33 (1H, s); 7.16 (1H, d), 3.34 (2H), 3.32 (3H, s), 3.01 (2H), 2.39 (2H, q), 2.31 (3H, s), 1.07 (3H, t).
Quellen und Nachweise
- ORD-Eintrag
- ord-7aef467fe6f943b7941320d5e4e7d8cc
- Quelldatensatz
- uspto-grants-2012_05
- Patentnummer
- US08173682B2
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