HCID 58413020, compound → HCID 71083020, compound

HRID 1921398Notes

Reaction equation

HRID 1921398 reaction equation
[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[S:15][C:14]([S:16]([Cl:19])(=[O:18])=[O:17])=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2].[F:20][C:21]1([F:30])[CH2:25][CH2:24][N:23]([CH2:26][CH2:27][CH2:28][NH2:29])[CH2:22]1>>[ClH:19].[F:30][C:21]1([F:20])[CH2:25][CH2:24][N:23]([CH2:26][CH2:27][CH2:28][NH:29][S:16]([C:14]2[S:15][C:11]([C:5]3[CH:4]=[C:3]([CH2:1][CH3:2])[C:8](=[O:9])[NH:7][C:6]=3[CH3:10])=[CH:12][CH:13]=2)(=[O:18])=[O:17])[CH2:22]1

Participants

3

Reactant 2

HCID 58413020HCID 58413020, compoundHCID 866103525-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride

Product 1

HCID 71083020HCID 71083020, compoundYield 39%

Procedure

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride is reacted with [3-(3,3-difluoro-pyrrolidin-1-yl)-propyl]-amine as described in Step 5, Example 24 to give the title compound (39% yield). LC/MS: RT 1.69 min; m/e=446 (M+H).

Sources & evidence

ORD record
ord-86b66cc694dd4340adb6463a2c9263e0
Source dataset
uspto-grants-2012_05
Patent number
US08173682B2

Reaction notes

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