1-(Pyridin-2-yl)ethan-1-amine → HCID 11590279, compound

HRID 1921399Notes

Reaction equation

HRID 1921399 reaction equation
[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[S:15][C:14]([S:16]([Cl:19])(=[O:18])=[O:17])=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2].[N:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[CH:26]([NH2:28])[CH3:27]>>[ClH:19].[N:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[CH:26]([NH:28][S:16]([C:14]1[S:15][C:11]([C:5]2[CH:4]=[C:3]([CH2:1][CH3:2])[C:8](=[O:9])[NH:7][C:6]=2[CH3:10])=[CH:12][CH:13]=1)(=[O:18])=[O:17])[CH3:27]

Participants

3

Reactant 2

HCID 5418771-(Pyridin-2-yl)ethan-1-amineHCID 866103525-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride

Product 1

HCID 11590279HCID 11590279, compoundYield 40%

Procedure

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)thiophene-2-sulfonyl chloride is reacted with (1-pyridin-2-yl)ethylamine as described in Step 5, Example 24 to give the title compound as a solid (40% yield). LC/MS: RT 2.40 min; m/e 404 (M+H); 1H NMR (δ, ppm): 11.82 (1H, br s), 8.81 (1H, d), 8.60 (1H, d), 8.06 (1H); 7.66 (3H, m); 7.23 (1H, s), 7.04 (1H, d), 4.64 (1H, m), 2.38 (2H, q), 2.30 (3H, s), 1.37 (3H, d), 1.10 (3H, t).

Sources & evidence

ORD record
ord-2310734cdd534b72a4851a2891f96bf9
Source dataset
uspto-grants-2012_05
Patent number
US08173682B2

Reaction notes

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