1-(4-Pyridyl)piperazine → HCID 67492177, compound

HRID 1921402Notes

Reaction equation

HRID 1921402 reaction equation
[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[O:15][C:14]([S:16]([Cl:19])(=[O:18])=[O:17])=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2].[N:20]1[CH:25]=[CH:24][C:23]([N:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)=[CH:22][CH:21]=1>>[ClH:19].[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[O:15][C:14]([S:16]([N:29]3[CH2:30][CH2:31][N:26]([C:23]4[CH:24]=[CH:25][N:20]=[CH:21][CH:22]=4)[CH2:27][CH2:28]3)(=[O:18])=[O:17])=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2]

Participants

3

Reactant 2

HCID 705171-(4-Pyridyl)piperazineHCID 86610360HCID 86610360, compound

Product 1

HCID 67492177HCID 67492177, compoundYield 72%

Procedure

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)furan-2-sulfonyl chloride is reacted with 1-(pyridin-4-yl)piperazine as described in Step 5, Example 24 to give the title compound as a solid (72% yield). LC/MS: RT 2.13 min; m/e 429 (M+H).

Sources & evidence

ORD record
ord-9259b4ea86f940ce82122111550869af
Source dataset
uspto-grants-2012_05
Patent number
US08173682B2

Reaction notes

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