2-(Pyridin-3-yl)ethan-1-amine → HCID 71083006, compound

HRID 1921405Notes

Reaction equation

HRID 1921405 reaction equation
[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[O:15][C:14]([S:16]([Cl:19])(=[O:18])=[O:17])=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2].[N:20]1[CH:25]=[CH:24][CH:23]=[C:22]([CH2:26][CH2:27][NH2:28])[CH:21]=1>>[ClH:19].[N:20]1[CH:25]=[CH:24][CH:23]=[C:22]([CH2:26][CH2:27][NH:28][S:16]([C:14]2[O:15][C:11]([C:5]3[CH:4]=[C:3]([CH2:1][CH3:2])[C:8](=[O:9])[NH:7][C:6]=3[CH3:10])=[CH:12][CH:13]=2)(=[O:18])=[O:17])[CH:21]=1

Participants

3

Reactant 2

HCID 8540512-(Pyridin-3-yl)ethan-1-amineHCID 86610360HCID 86610360, compound

Product 1

HCID 71083006HCID 71083006, compoundYield 34%

Procedure

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)furan-2-sulfonyl chloride is reacted with (2-pyridin-3-yl)ethylamine as described in Step 5, Example 24 to give the title compound as a solid (34% yield). LC/MS: RT 2.00 min; m/e 388 (M+H); 1H NMR (δ, ppm): 8.75 (2H), 7.90-8.36 (3H), 7.45 (1H, s), 7.13 (1H, d); 6.68 (1H, d), 3.27 (2H), 2.96 (2H), 2.36 (3H, s), 2.40 (2H), 1.11 (3H, t).

Sources & evidence

ORD record
ord-05a5aa094654499a8ce81833801fc646
Source dataset
uspto-grants-2012_05
Patent number
US08173682B2

Reaction notes

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