1-Methylhomopiperazine → HCID 67492162, compound

HRID 1921408Notes

Reaction equation

[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[O:15][C:14]([S:16]([Cl:19])(=[O:18])=[O:17])=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2].[CH3:20][N:21]1[CH2:27][CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[ClH:19].[CH2:1]([C:3]1[C:8](=[O:9])[NH:7][C:6]([CH3:10])=[C:5]([C:11]2[O:15][C:14]([S:16]([N:24]3[CH2:25][CH2:26][CH2:27][N:21]([CH3:20])[CH2:22][CH2:23]3)(=[O:18])=[O:17])=[CH:13][CH:12]=2)[CH:4]=1)[CH3:2]

Participants

Reactant 2

HCID 2283491-Methylhomopiperazine

HCID 86610360HCID 86610360, compound

Product 1

HCID 67492162HCID 67492162, compoundYield 73%

Procedure

5-(5-Ethyl-2-methyl-6-oxo-1,6-dihydropyridin-3-yl)furan-2-sulfonyl chloride is reacted with 1-methyl-1,4-diazepane as described in Steps 5 and 6, Example 1 to give the title compound as a solid (73% yield). LC/MS: RT 2.00 min; m/e 380 (M+H); 1H NMR (CDCl3, δ, ppm): 11.81 (1H), 7.51 (1H), 7.29 (1H), 6.78 (1H); 3.85 (2H), 3.46 (6H), 3.19 (2H), 2.78 (3H), 2.40 (5H), 1.09 (3H, t).

Sources & evidence

ORD record: ord-60b186b9b9f74f3b852c3a3f920b120a
Source dataset: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08173682B2

Reaction notes

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